Quarterly report pursuant to Section 13 or 15(d)

Significant Agreements - Additional Information (Details)

v3.22.2.2
Significant Agreements - Additional Information (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Dec. 16, 2021
USD ($)
ft²
Jun. 18, 2021
shares
Jun. 07, 2021
USD ($)
Apr. 30, 2021
USD ($)
Jan. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
shares
Sep. 30, 2022
USD ($)
shares
Jun. 30, 2022
shares
Sep. 30, 2021
USD ($)
shares
Jun. 30, 2021
shares
Mar. 31, 2021
shares
Sep. 30, 2022
USD ($)
shares
Sep. 30, 2021
USD ($)
shares
Dec. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
shares
May 07, 2021
shares
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Common stock, shares, issued | shares             58,149,317         58,149,317   58,010,823    
Research and development             $ 18,302,000   $ 8,683,000     $ 54,325,000 $ 26,727,000      
General and administrative             7,852,000   $ 5,919,000     24,563,000 $ 14,776,000      
Common stock issued upon exercise of options | shares                 0       922,208      
Future minimum lease payments             7,517,000         7,517,000        
Operating lease liability             $ 7,007,000         7,007,000        
Common Stock                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Common stock issued upon exercise of options | shares             17,000 43,945   3,383 918,825          
Stanford Exclusive License Agreement                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Upfront license fees received           $ 50,000.0                    
Common stock, shares, issued | shares           600,000                 600,000 640,861
Common stock additional paid in capital           $ 2,800,000                 $ 2,800,000  
Purchase of shares in private financings percentage           10.00%                    
Shares repurchased | shares   624,845                            
Research and development                             2,800,000  
General and administrative                             200,000  
Annual maintenance fees             $ 0         10,000.0        
First commercial sale                             50,000.0  
Subsequent year commercial sale                             200,000.0  
Maximum future development and regulatory milestones payments                       5,300,000        
Sale-based milestones payments                       7,500,000        
Milestone payments                           $ 0    
Stanford Exclusive License Agreement | Research and Development Expenses                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Milestone payments             500,000         500,000        
Stanford Exclusive License Agreement | Patents Fees Member                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
General and administrative             0         0        
Stanford Exclusive License Agreement | First Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             5,000.0  
Stanford Exclusive License Agreement | Second Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             10,000.0  
Stanford Exclusive License Agreement | Third Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             10,000.0  
Stanford Exclusive License Agreement | Fourth Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             25,000.0  
Stanford Exclusive License Agreement | Fifth Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             25,000.0  
Stanford Exclusive License Agreement | Sixth Year                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                             $ 25,000.0  
License Agreement with Stanford | Common Stock                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Shares repurchased | shares   624,845               624,845            
First Option Agreement                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Common stock, shares, issued | shares         132,137                      
License execution fee         $ 10,000.0                      
Option agreement expiration term         18 months                      
Second Option Agreement                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Annual maintenance fees                       $ 10,000.0        
Common stock issued upon exercise of options | shares                       0        
Options fee       $ 30,000.0                        
LCGM Service Agreement                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Research and development             1,700,000         $ 4,500,000        
IDT License Agreement                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Research and development             0         0        
Milestone payments             0         0        
Exercise fee     $ 500,000                          
Upfront payment     3,000,000.0                          
Milestones probable             0         0        
IDT License Agreement | Research and Development Expenses                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Total consideration                           3,000,000.0    
IDT License Agreement | Maximum                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Upfront payment     5,300,000                          
IDT License Agreement | Beta Thalassemia and Lysosomal Storage Disorders Fields                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Exercise fee     1,000,000.0                          
Upfront payment     $ 8,800,000                          
Bayside Lease                                
Research And Development Arrangement Contract To Perform For Others [Line Items]                                
Office and Laboratory Space | ft² 85,165                              
Lease commencement date Sep. 15, 2023                              
Lease term 120 months                              
Future minimum lease payments $ 81,000,000.0                              
Term of contract 10 years                              
Security Deposit             1,600,000         1,600,000   1,600,000    
Tenant improvement allowance                       14,900,000        
Tenant improvements             2,600,000         2,600,000        
Operating lease liability             $ 0         $ 0   $ 0